Archive for June, 2011

Jun 30th, 2011

Alertness & Memory – Part 4

Once the ammonia has been has been converted, the brain can use glutamine, like the sugar glucose, as a source of energy. So taking glutamine is almost like plugging your brain into a free fuel source. Not only does it make you feel healthier, it can actually benefit your work. Students, for example, fine that taking glutamine supplements in the evening helps them concentrate on homework; they can also work much later in to the night without feeling tired. Unlike the caffeine contained in tea and coffee, glutamine stimulates, the brain by naturally supporting the brain’s metabolic pathways. You feel livelier when you take the glutamine because it unblocks the vitality we all possess but rarely release – unlike coffee, which provides and artificial stimulation at the expense of your health. Students have also take glutamine before examinations. They report greater mental alertness and clarity, and a few of the doubts that often surface during exams.

Jun 29th, 2011

Alertness & Memory – Part 3

As 25% of all the body’s metabolic activity occurs in the brain, the waste product of this activity, ammonia, will be much more concentrated there than anywhere else. Even a minor shortage. of glutamic acid causes the ammonia levels to rise slightly, leading to fatigue, confusion, and inability concentrate, and exaggerated mood swings – problems that are common to almost all of us at some point. Supplementing with extra glutamic acid helps avoid these symptoms by combining with the ammonia to produce nontoxic glutamine.

There is, however, one problem, with taking supplementary glutamic acid. Scientists have found that it doesn’t easily cross the blood-brain barrier, a membrane that protects the brain cells from poisons carried in the blood. Glutamine, on the other hand, crosses this barrier with ease. One in the brain, it will convert to glutamic acid before combining with ammonia and converting back to glutamine. This why we recommend that you take glutamine rather than glutamic acid.

Come back tomorrow for part 4!

Jun 28th, 2011

Alertness & Memory – Part 2

Ammonia is created in the body by the breakdown of worn-out protein, a natural and continuous process of the body’s metabolism. Wherever protein is used – and that means everywhere in the body – ammonia is certain to be present.

The process your body employs to clear this ammonia is called the urea cycle – a metabolic pathway that converts ammonia to urea, which the body can harmlessly excrete in its urine. The first and most important stage of this pathway is the reaction of glutamic acid with ammonia. The two combine to produce the harmless chemical glutamic acid, much of the ammonia will remain unconverted. And the implications of this for the brain are frightening!

Come back tomorrow for part 3 – we’re heading somewhere!

Jun 27th, 2011

Alertness & Memory – Part 1

Some amino acids can be helpful even if you are mentally & emotionally healthy. For example, at times, you may be less alert than you’d like, or you may have days when you find it impossible to concentrate or remember. Amino acids can help with these days!


To maintain effective brain function, one of the most helpful free-form amino supplements is glutamic acid. It’s importance lies in the fact that the body needs it to rid the brain of ammonia – a highly poisonous natural chemical. If allowed to accumulate in the body, ammonia causes irritability, nausea, vomiting, tremors, hallucinations, and eventually death.

Come back tomorrow for Part 2!

Jun 17th, 2011

Micronutrients & Amino Acids, Main Regulators of Physiological Processes – Part 20

The most important consequence of the hypothesis lies in the fact that it is essential to study intake of our (semi)-essential nutrients before drawing all our attention to medicines or manipulating genetics. It might be possible that congenital diseases are the consequence of suboptimal food intake, such as is the case in cretinism and iodine deficiency. It is essential that we do our research as part of the whole puzzle, never leave the whole picture out of sight and fit the results into it. If the hypothesis is true it could create a paradigm shift, with huge possibilities for metabolic and preventive medicine.

We first have to study how to nurture nature before we change nature itself.

by R.H. Verheesen, C.M. Schweitzer

Jun 16th, 2011

Micronutrients & Amino Acids, Main Regulators of Physiological Processes – Part 19

Inducing hyperthyroidism will only be possible in optimal conditions, for example optimum ferro for TPO formation, sufficient vitamin D for tyrosine hydroxylase and sufficient selenium for deiodinase activity. Instead of focusing on one single micronutrient or amino acid, research should focus on the interactions between them. Than it offers real possibilities to determine the facts that contribute to optimal health. In modern food industry huge changes take place. Animal food is enriched with amino acids (e.g. L-lysine) or depleted for other amino acids. Eventually, this affects protein content of food and in that way food intake of human beings.

Assuming mitochondria to be bacteria, living in complete symbiosis with the human cell, we will have to look upon mitochondria as a solitary living organism from a symbiotic point of view. Mitochondrial diseases may be caused by insufficient nutrition. To ameliorate the cell circumstances, by providing optimal nutrition, fitting the mitochondrial and host cells needs, eventually human life is positively affected. In that respect, negatively contributing environmental circumstances have to be taken in account as well, such as pollutants.

Come back tomorrow for the conclusion!

by R.H. Verheesen, C.M. Schweitzer

Jun 15th, 2011

Micronutrients & Amino Acids, Main Regulators of Physiological Processes – Part 18

Consequences of the hypothesis

The consequences of our hypothesis could lead to changing views on metabolism and mechanisms of disease. If it is true that amino acids are the most important elements in metabolism and directly influence it, it means that they are evenly able to cause and/or modify diseases. Given the fact that shortages in amino acids can cause several diseases, it seems logic to suppose that disbalances in amino acids are able to do this as well. From this point of view, as shortage of tyrosine can lead to hypothyroidism, too much tyrosine could in a similar way lead to hyperthyroidism.

Come back tomorrow for more!

by R.H. Verheesen, C.M. Schweitzer

Jun 14th, 2011

Micronutrients & Amino acids, Main Regulators of Physiological Processes – Part 17

Testing the Hypothesis (cont.)

7. In case of obesities it is known that inhibition of tyrosine hydroxylase leads to hyperleptinaemia. In that respect it seems of importance to study micronutrients known to play a crucial role in the thyroid-tyrosine metabolism on leptin levels, such as vitamin D, tyrosine and iodine.

8. In case of skin cancer the effects of iodine protection on the radiating effects of UV light on the skin could be studied. Given the large numbers of iodine deficiency, with increas- ing numbers in countries with an increase of incidence of skin cancer such as Australia and Europe, this increased incidence could be related to a less protective effect of iodine on hyaluronate degradation by UVB. Iodine deficiency could even be related to the vitamin D deficiency, given the fact that the skin could be less productive because of a higher damage rate by irradiation and less possibilities to withstand the oxidative stress.

9. To study the influence of micronutrients on the mobility of the mobile genetic elements it would be of interest to study the changes in the non-encoding DNA related to different micronutrient levels.

10. Above mentioned ideas are only some of the many possibilities for further investigation. Eventually, further studies should lead to insight in nutrition balance for human cells, the intracellular living bacteria and for our environment as well. Only in that way an optimal human adaptive physiological system will exist.

Come back tomorrow for more!

(by R.H. Verheesen, C.M. Schweitzer)

Jun 13th, 2011

Micronutrients & Amino acids, Main Regulators of Physiological Processes – Part 16

Testing the Hypothesis (cont.)

4. Amino acids as regulators of chemical processes. It seems logic to study the effect of single amino acid supply on bio- chemical balances, such as tyrosine and TSH, tryptophan and serotonin.

5. It would be interesting to study whether apoptosis can be induced by changing the amino acid content of food. Moreover, it is worthwhile to study the effect of nutrients on the number and activity of mitochondria.

6. In clinical practice it seems logic to see in ADHD populations whether the benefit of artificial increase of dopamine levels by methylphenidate, could be reached by supplementation of the above mentioned factors that contribute towards an optimal dopamine metabolism. Special attention should be given to iodine, vitamin D and tyrosine.

Come back tomorrow for more!

by R.H. Verheesen, C.M. Schweitzer

Jun 10th, 2011

Micronutrients & Amino acids, Main Regulators of Physiological Processes – Part 15

Testing the hypothesis

1. Storage of amino acids in proteins as a buffer for too low or too high concentrations of amino acids, assuming one codon encodes for more than one amino acid. In experimental studies groups of animals could be given a single amino acid or micronutrient besides their regular food, after which comparison of body proteins could possibly point to a difference in amino acid sequence although the same codon sequence is investigated.

2. Tyrosine as a regulator of chemical processes. First it could be studied whether it is possible to induce hypo- or hyperthyroidism in animals by tyrosine depletion or supply. Optimal nutritional environment will be necessary to induce this.

3. To study the influence of salt intake on iodine excretion in urine animals could be given various amounts of sodium under standard iodine intake. The same could be done for pollutants such as thiocyanate. Furthermore it is of interest to find the triggers for increased iodine uptake by the kidney. Several factors could be investigated for instance iodine itself, tyrosine or dopamine.

Come back Monday for more!

(by R.H. Verheesen, C.M. Schweitzer)